A number of upperclasswomen outstanding in their faith are chosen each year to help the Campus Ministry adult team run the various programs throughout the school year. They lead retreats, organize liturgies, meetings, prayer services, and outreach opportunities. The interview process takes place in the spring for the following year.
Once a month Campus Ministry sponsors a drive and/or community outreach that is often in response to the immediate needs of the local or global communities. Contributions from La Reina have helped to build Notre Dame schools in Buseesa, Uganda since their foundation, and continue to sponsor quarterly mission drives. A personal favorite of many students is the annual Christmas Adopt-a-Family drive in which religion classes adopt one or more families and supply them with a Christmas they would not have had otherwise. Recent outreach has included visits to Catholic Worker in Los Angeles; hosting a Handicapables Prayer Service and Luncheon in the La Reina cafeteria; and collecting toiletry/socks for the homeless.
Outreach also includes the Christian Service hours that every student completes in order to graduate from La Reina High School. Junior high students are asked to do five hours a year. Senior high students do at least twenty hours a year, but most complete nearly twice that amount.